Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4561716..4562332 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYP10_RS23030 Protein ID WP_080336832.1
Coordinates 4561716..4562087 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag NYP10_RS23035 Protein ID WP_015569912.1
Coordinates 4562090..4562332 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS23015 (NYP10_23025) 4559216..4560118 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
NYP10_RS23020 (NYP10_23030) 4560115..4560750 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
NYP10_RS23025 (NYP10_23035) 4560747..4561676 + 930 WP_023323896.1 formate dehydrogenase accessory protein FdhE -
NYP10_RS23030 (NYP10_23040) 4561716..4562087 - 372 WP_080336832.1 type II toxin-antitoxin system VapC family toxin Toxin
NYP10_RS23035 (NYP10_23045) 4562090..4562332 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
NYP10_RS23040 (NYP10_23050) 4562531..4563451 + 921 WP_045343465.1 alpha/beta hydrolase -
NYP10_RS23045 (NYP10_23055) 4563460..4564401 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
NYP10_RS23050 (NYP10_23060) 4564446..4564883 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
NYP10_RS23055 (NYP10_23065) 4564880..4565761 - 882 WP_003861949.1 virulence factor BrkB family protein -
NYP10_RS23060 (NYP10_23070) 4565755..4566354 - 600 WP_003861947.1 glucose-1-phosphatase -
NYP10_RS23065 (NYP10_23075) 4566473..4567273 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T257986 WP_080336832.1 NZ_CP104471:c4562087-4561716 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT257986 WP_015569912.1 NZ_CP104471:c4562332-4562090 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References