Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3756771..3757428 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NYP10_RS19185 Protein ID WP_022649305.1
Coordinates 3756771..3757181 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NYP10_RS19190 Protein ID WP_003863437.1
Coordinates 3757162..3757428 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS19165 (NYP10_19175) 3752769..3754502 - 1734 WP_047054429.1 single-stranded-DNA-specific exonuclease RecJ -
NYP10_RS19170 (NYP10_19180) 3754508..3755221 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NYP10_RS19175 (NYP10_19185) 3755250..3756146 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NYP10_RS19180 (NYP10_19190) 3756248..3756769 + 522 WP_003863440.1 flavodoxin FldB -
NYP10_RS19185 (NYP10_19195) 3756771..3757181 - 411 WP_022649305.1 protein YgfX Toxin
NYP10_RS19190 (NYP10_19200) 3757162..3757428 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NYP10_RS19195 (NYP10_19205) 3757723..3758703 + 981 WP_047054431.1 tRNA-modifying protein YgfZ -
NYP10_RS19200 (NYP10_19210) 3758769..3759860 - 1092 WP_227661289.1 IS4 family transposase -
NYP10_RS19205 (NYP10_19215) 3760077..3760736 - 660 WP_003863433.1 hemolysin III family protein -
NYP10_RS19210 (NYP10_19220) 3761003..3761734 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T257985 WP_022649305.1 NZ_CP104471:c3757181-3756771 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT257985 WP_003863437.1 NZ_CP104471:c3757428-3757162 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References