Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3078581..3080364 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYP10_RS15935 Protein ID WP_023314540.1
Coordinates 3078581..3079930 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag NYP10_RS15940 Protein ID WP_003859317.1
Coordinates 3079927..3080364 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS15910 (NYP10_15920) 3074404..3075339 - 936 WP_045343060.1 tRNA dihydrouridine(16) synthase DusC -
NYP10_RS15915 (NYP10_15925) 3075508..3075903 + 396 WP_003859308.1 CidA/LrgA family protein -
NYP10_RS15920 (NYP10_15930) 3075900..3076595 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
NYP10_RS15925 (NYP10_15935) 3076724..3077608 + 885 WP_003859312.1 cytidine deaminase -
NYP10_RS15930 (NYP10_15940) 3077736..3078446 + 711 WP_047054751.1 outer membrane permeability protein SanA -
NYP10_RS15935 (NYP10_15945) 3078581..3079930 + 1350 WP_023314540.1 HipA domain-containing protein Toxin
NYP10_RS15940 (NYP10_15950) 3079927..3080364 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
NYP10_RS15945 (NYP10_15955) 3080403..3081413 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
NYP10_RS15950 (NYP10_15960) 3081429..3082949 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
NYP10_RS15955 (NYP10_15965) 3083029..3084027 - 999 WP_003859322.1 galactose/glucose ABC transporter substrate-binding protein MglB -
NYP10_RS15960 (NYP10_15970) 3084323..3085345 - 1023 WP_045337656.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51137.78 Da        Isoelectric Point: 4.6562

>T257984 WP_023314540.1 NZ_CP104471:3078581-3079930 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT257984 WP_003859317.1 NZ_CP104471:3079927-3080364 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References