Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2306291..2307030 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NYP10_RS12350 Protein ID WP_047055520.1
Coordinates 2306291..2306776 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag NYP10_RS12355 Protein ID WP_045336276.1
Coordinates 2306764..2307030 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS12330 (NYP10_12340) 2302445..2303203 - 759 WP_047055523.1 trans-aconitate 2-methyltransferase -
NYP10_RS12335 (NYP10_12345) 2303288..2303872 - 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
NYP10_RS12340 (NYP10_12350) 2303959..2304717 + 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
NYP10_RS12345 (NYP10_12355) 2304822..2306114 + 1293 WP_047055521.1 glycosyl hydrolase family 28 protein -
NYP10_RS12350 (NYP10_12360) 2306291..2306776 - 486 WP_047055520.1 GNAT family N-acetyltransferase Toxin
NYP10_RS12355 (NYP10_12365) 2306764..2307030 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
NYP10_RS12360 (NYP10_12370) 2307094..2308023 - 930 WP_045894389.1 LysR family transcriptional regulator -
NYP10_RS12365 (NYP10_12375) 2308153..2309541 + 1389 WP_047055517.1 MFS transporter -
NYP10_RS12370 (NYP10_12380) 2309563..2310558 - 996 WP_261300456.1 DUF2891 domain-containing protein -
NYP10_RS12375 (NYP10_12385) 2310568..2311554 - 987 WP_047055515.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T257979 WP_047055520.1 NZ_CP104471:c2306776-2306291 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLGEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT257979 WP_045336276.1 NZ_CP104471:c2307030-2306764 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References