Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1063487..1064107 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag NYP10_RS06245 Protein ID WP_015571250.1
Coordinates 1063487..1063705 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag NYP10_RS06250 Protein ID WP_006809850.1
Coordinates 1063733..1064107 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS06215 (NYP10_06220) 1059499..1059759 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
NYP10_RS06220 (NYP10_06225) 1059762..1059902 + 141 WP_032608666.1 type B 50S ribosomal protein L36 -
NYP10_RS06225 (NYP10_06230) 1059899..1060609 - 711 WP_045337215.1 GNAT family protein -
NYP10_RS06230 (NYP10_06235) 1060711..1062171 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
NYP10_RS06235 (NYP10_06240) 1062143..1062610 - 468 WP_022650495.1 YlaC family protein -
NYP10_RS06240 (NYP10_06245) 1062727..1063278 - 552 WP_022650496.1 maltose O-acetyltransferase -
NYP10_RS06245 (NYP10_06250) 1063487..1063705 - 219 WP_015571250.1 HHA domain-containing protein Toxin
NYP10_RS06250 (NYP10_06255) 1063733..1064107 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
NYP10_RS06255 (NYP10_06260) 1064617..1067763 - 3147 WP_047054540.1 multidrug efflux RND transporter permease subunit AcrB -
NYP10_RS06260 (NYP10_06265) 1067786..1068979 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T257976 WP_015571250.1 NZ_CP104471:c1063705-1063487 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT257976 WP_006809850.1 NZ_CP104471:c1064107-1063733 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References