Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1063487..1064107 | Replicon | chromosome |
Accession | NZ_CP104471 | ||
Organism | Enterobacter hormaechei strain 80014967 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A837FFM2 |
Locus tag | NYP10_RS06245 | Protein ID | WP_015571250.1 |
Coordinates | 1063487..1063705 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | F5RUW7 |
Locus tag | NYP10_RS06250 | Protein ID | WP_006809850.1 |
Coordinates | 1063733..1064107 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NYP10_RS06215 (NYP10_06220) | 1059499..1059759 | + | 261 | WP_015571255.1 | type B 50S ribosomal protein L31 | - |
NYP10_RS06220 (NYP10_06225) | 1059762..1059902 | + | 141 | WP_032608666.1 | type B 50S ribosomal protein L36 | - |
NYP10_RS06225 (NYP10_06230) | 1059899..1060609 | - | 711 | WP_045337215.1 | GNAT family protein | - |
NYP10_RS06230 (NYP10_06235) | 1060711..1062171 | + | 1461 | WP_022650494.1 | PLP-dependent aminotransferase family protein | - |
NYP10_RS06235 (NYP10_06240) | 1062143..1062610 | - | 468 | WP_022650495.1 | YlaC family protein | - |
NYP10_RS06240 (NYP10_06245) | 1062727..1063278 | - | 552 | WP_022650496.1 | maltose O-acetyltransferase | - |
NYP10_RS06245 (NYP10_06250) | 1063487..1063705 | - | 219 | WP_015571250.1 | HHA domain-containing protein | Toxin |
NYP10_RS06250 (NYP10_06255) | 1063733..1064107 | - | 375 | WP_006809850.1 | Hha toxicity modulator TomB | Antitoxin |
NYP10_RS06255 (NYP10_06260) | 1064617..1067763 | - | 3147 | WP_047054540.1 | multidrug efflux RND transporter permease subunit AcrB | - |
NYP10_RS06260 (NYP10_06265) | 1067786..1068979 | - | 1194 | WP_022650498.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8583.95 Da Isoelectric Point: 8.9008
>T257976 WP_015571250.1 NZ_CP104471:c1063705-1063487 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14497.28 Da Isoelectric Point: 4.8989
>AT257976 WP_006809850.1 NZ_CP104471:c1064107-1063733 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FFM2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FGN8 |