257974

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yafW/CbtA-CbeA
Location 403290..404083 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag NYP10_RS03065 Protein ID WP_000854726.1
Coordinates 403290..403667 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EBQ7
Locus tag NYP10_RS03070 Protein ID WP_001548930.1
Coordinates 403757..404083 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS03045 (NYP10_03045) 400802..401422 - 621 WP_032608268.1 DUF2238 domain-containing protein -
NYP10_RS03050 (NYP10_03050) 401669..402511 - 843 WP_001548928.1 DUF4942 domain-containing protein -
NYP10_RS03055 (NYP10_03055) 402596..402793 - 198 WP_000839269.1 DUF957 domain-containing protein -
NYP10_RS03060 (NYP10_03060) 402805..403293 - 489 WP_001547769.1 DUF5983 family protein -
NYP10_RS03065 (NYP10_03065) 403290..403667 - 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
NYP10_RS03070 (NYP10_03070) 403757..404083 - 327 WP_001548930.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
NYP10_RS03075 (NYP10_03075) 404102..404323 - 222 WP_000691994.1 DUF987 domain-containing protein -
NYP10_RS03080 (NYP10_03080) 404332..404808 - 477 WP_000811693.1 RadC family protein -
NYP10_RS03085 (NYP10_03085) 404824..405282 - 459 WP_000211838.1 antirestriction protein -
NYP10_RS03090 (NYP10_03090) 405380..405619 - 240 WP_000194654.1 DUF905 family protein -
NYP10_RS03095 (NYP10_03095) 405696..406163 - 468 WP_045351203.1 protein YkfB -
NYP10_RS03100 (NYP10_03100) 406187..406630 - 444 WP_045351202.1 lipoprotein YafY -
NYP10_RS03105 (NYP10_03105) 406630..406866 - 237 WP_001115854.1 protein YpjK -
NYP10_RS03110 (NYP10_03110) 406903..407604 - 702 WP_001548933.1 WYL domain-containing protein -
NYP10_RS03115 (NYP10_03115) 407822..408430 - 609 Protein_377 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - wza 402805..427925 25120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T257974 WP_000854726.1 NZ_CP104471:c403667-403290 [Enterobacter hormaechei]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12301.97 Da        Isoelectric Point: 7.0273

>AT257974 WP_001548930.1 NZ_CP104471:c404083-403757 [Enterobacter hormaechei]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure
AlphaFold DB S1EBQ7

References