Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 96941..97680 Replicon plasmid pIncFIB_Silv108
Accession NZ_CP104452
Organism Raoultella ornithinolytica strain MQB_Silv_108

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag N2J37_RS29290 Protein ID WP_076752153.1
Coordinates 97195..97680 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag N2J37_RS29285 Protein ID WP_012540086.1
Coordinates 96941..97207 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2J37_RS29255 (N2J37_29255) 92171..92707 - 537 WP_013087166.1 GNAT family N-acetyltransferase -
N2J37_RS29260 (N2J37_29260) 92832..94583 - 1752 WP_175406650.1 arsenical pump-driving ATPase -
N2J37_RS29265 (N2J37_29265) 94610..94972 - 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -
N2J37_RS29270 (N2J37_29270) 95048..95593 - 546 WP_047365773.1 sigma-70 family RNA polymerase sigma factor -
N2J37_RS29275 (N2J37_29275) 95602..96315 - 714 WP_013087170.1 arsenical resistance protein ArsH -
N2J37_RS29280 (N2J37_29280) 96317..96640 - 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
N2J37_RS29285 (N2J37_29285) 96941..97207 + 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
N2J37_RS29290 (N2J37_29290) 97195..97680 + 486 WP_076752153.1 GNAT family N-acetyltransferase Toxin
N2J37_RS29295 (N2J37_29295) 97964..98116 + 153 WP_223526259.1 DUF5431 family protein -
N2J37_RS29300 (N2J37_29300) 98064..98180 + 117 WP_223176086.1 type I toxin-antitoxin system Hok family toxin -
N2J37_RS29305 (N2J37_29305) 99085..99357 + 273 WP_137055850.1 hypothetical protein -
N2J37_RS29310 (N2J37_29310) 99460..99807 + 348 WP_076752140.1 hypothetical protein -
N2J37_RS29315 (N2J37_29315) 99896..100126 + 231 WP_076752138.1 hypothetical protein -
N2J37_RS29320 (N2J37_29320) 100173..101006 + 834 WP_076752137.1 N-6 DNA methylase -
N2J37_RS29325 (N2J37_29325) 101210..101440 - 231 WP_076752135.1 hypothetical protein -
N2J37_RS29330 (N2J37_29330) 101632..102162 + 531 WP_076752134.1 antirestriction protein -
N2J37_RS29335 (N2J37_29335) 102200..102676 - 477 WP_076752132.1 transglycosylase SLT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..138718 138718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17838.68 Da        Isoelectric Point: 10.0748

>T257967 WP_076752153.1 NZ_CP104452:97195-97680 [Raoultella ornithinolytica]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT257967 WP_012540086.1 NZ_CP104452:96941-97207 [Raoultella ornithinolytica]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References