Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 5033130..5033709 Replicon chromosome
Accession NZ_CP104450
Organism Raoultella ornithinolytica strain MQB_Silv_108

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag N2J37_RS24475 Protein ID WP_260990351.1
Coordinates 5033422..5033709 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag N2J37_RS24470 Protein ID WP_160873248.1
Coordinates 5033130..5033435 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2J37_RS24445 (N2J37_24445) 5028337..5029401 - 1065 WP_004857527.1 DUF2955 domain-containing protein -
N2J37_RS24450 (N2J37_24450) 5029391..5030458 - 1068 WP_004857525.1 HlyD family secretion protein -
N2J37_RS24455 (N2J37_24455) 5030465..5030929 - 465 WP_004857523.1 MarR family transcriptional regulator -
N2J37_RS24460 (N2J37_24460) 5031220..5031384 - 165 WP_004857521.1 DUF1127 domain-containing protein -
N2J37_RS24465 (N2J37_24465) 5031562..5032974 + 1413 WP_015585221.1 PLP-dependent aminotransferase family protein -
N2J37_RS24470 (N2J37_24470) 5033130..5033435 - 306 WP_160873248.1 BrnA antitoxin family protein Antitoxin
N2J37_RS24475 (N2J37_24475) 5033422..5033709 - 288 WP_260990351.1 BrnT family toxin Toxin
N2J37_RS24480 (N2J37_24480) 5033826..5034245 - 420 WP_260990352.1 FosA family fosfomycin resistance glutathione transferase -
N2J37_RS24485 (N2J37_24485) 5034249..5035129 - 881 Protein_4808 LysR family transcriptional regulator -
N2J37_RS24490 (N2J37_24490) 5035217..5035987 + 771 WP_152292992.1 NAD(P)H-dependent oxidoreductase -
N2J37_RS24495 (N2J37_24495) 5036135..5036713 + 579 WP_113991322.1 TetR/AcrR family transcriptional regulator -
N2J37_RS24500 (N2J37_24500) 5036857..5037669 + 813 WP_004857492.1 winged helix-turn-helix domain-containing protein -
N2J37_RS24505 (N2J37_24505) 5037666..5038184 + 519 WP_015585229.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(34-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11037.46 Da        Isoelectric Point: 7.0747

>T257965 WP_260990351.1 NZ_CP104450:c5033709-5033422 [Raoultella ornithinolytica]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRQDRYENGEHRWQTIGLVHGIIVILVVHSVRFESGAEVIRIIS
ARKADGKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11709.23 Da        Isoelectric Point: 9.4631

>AT257965 WP_160873248.1 NZ_CP104450:c5033435-5033130 [Raoultella ornithinolytica]
MSMVKHKRDNPTALTAQREDELKALARKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIREQNKKS

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References