Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3221417..3223020 Replicon chromosome
Accession NZ_CP104450
Organism Raoultella ornithinolytica strain MQB_Silv_108

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag N2J37_RS15685 Protein ID WP_015584335.1
Coordinates 3221689..3223020 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag N2J37_RS15680 Protein ID WP_032717448.1
Coordinates 3221417..3221689 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2J37_RS15655 (N2J37_15655) 3217026..3218267 + 1242 WP_064359335.1 sensor domain-containing diguanylate cyclase -
N2J37_RS15660 (N2J37_15660) 3218287..3218946 + 660 WP_260990138.1 class I SAM-dependent methyltransferase -
N2J37_RS15665 (N2J37_15665) 3219134..3220087 + 954 WP_004861921.1 hypothetical protein -
N2J37_RS15670 (N2J37_15670) 3220229..3220654 + 426 WP_260990139.1 hypothetical protein -
N2J37_RS15675 (N2J37_15675) 3220660..3221214 + 555 WP_260990140.1 RNA polymerase sigma factor -
N2J37_RS15680 (N2J37_15680) 3221417..3221689 + 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N2J37_RS15685 (N2J37_15685) 3221689..3223020 + 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
N2J37_RS15690 (N2J37_15690) 3222953..3224359 - 1407 WP_015584334.1 glycoside hydrolase family 10 protein -
N2J37_RS15695 (N2J37_15695) 3225074..3226132 + 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
N2J37_RS15700 (N2J37_15700) 3226232..3227146 + 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T257963 WP_015584335.1 NZ_CP104450:3221689-3223020 [Raoultella ornithinolytica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT257963 WP_032717448.1 NZ_CP104450:3221417-3221689 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References