Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
Location | 272385..272973 | Replicon | plasmid unnamed2 |
Accession | NZ_CP104447 | ||
Organism | Acinetobacter baumannii strain 2021CK-01407 |
Toxin (Protein)
Gene name | brnT | Uniprot ID | N8SM64 |
Locus tag | N5T86_RS01155 | Protein ID | WP_000438825.1 |
Coordinates | 272385..272672 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | brnA | Uniprot ID | D3JXQ4 |
Locus tag | N5T86_RS01160 | Protein ID | WP_004728120.1 |
Coordinates | 272659..272973 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5T86_RS01135 (N5T86_01140) | 268565..269757 | + | 1193 | WP_085955245.1 | IS3-like element ISKpn18 family transposase | - |
N5T86_RS01140 (N5T86_01145) | 269876..270490 | + | 615 | WP_125281634.1 | recombinase family protein | - |
N5T86_RS01145 (N5T86_01150) | 270556..271359 | + | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
N5T86_RS01150 (N5T86_01155) | 271359..272195 | + | 837 | WP_040110386.1 | APH(6)-I family aminoglycoside O-phosphotransferase | - |
N5T86_RS01155 (N5T86_01160) | 272385..272672 | + | 288 | WP_000438825.1 | BrnT family toxin | Toxin |
N5T86_RS01160 (N5T86_01165) | 272659..272973 | + | 315 | WP_004728120.1 | BrnA antitoxin family protein | Antitoxin |
N5T86_RS01165 (N5T86_01170) | 273140..273583 | - | 444 | WP_260744098.1 | hypothetical protein | - |
N5T86_RS01170 (N5T86_01175) | 273661..274629 | + | 969 | WP_252513945.1 | IS30 family transposase | - |
N5T86_RS01175 (N5T86_01180) | 274831..275133 | + | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
N5T86_RS01180 (N5T86_01185) | 275134..275415 | + | 282 | WP_000985609.1 | putative addiction module antidote protein | - |
N5T86_RS01185 (N5T86_01190) | 275495..275914 | - | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
N5T86_RS01190 (N5T86_01195) | 276054..276374 | + | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
N5T86_RS01195 (N5T86_01200) | 276367..276639 | + | 273 | WP_000369781.1 | NadS family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaOXA-58 / tet(X3) / sul2 / aph(3'')-Ib / aph(6)-Id / msr(E) / mph(E) / ARR-3 / qacE / sul1 / blaNDM-1 / aph(3')-VI | - | 1..335722 | 335722 | |
- | inside | IScluster/Tn | aph(3'')-Ib / aph(6)-Id / msr(E) / mph(E) | - | 261718..279547 | 17829 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11304.70 Da Isoelectric Point: 5.6205
>T257949 WP_000438825.1 NZ_CP104447:272385-272672 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
Download Length: 288 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A8TVQ4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A8TRI9 |