257946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4371531..4372117 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag N1H43_RS21380 Protein ID WP_042014162.1
Coordinates 4371887..4372117 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N1H43_RS21375 Protein ID WP_000593555.1
Coordinates 4371531..4371890 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS21350 (4367663) 4367663..4368607 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
N1H43_RS21355 (4368604) 4368604..4369437 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N1H43_RS21360 (4369437) 4369437..4370201 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N1H43_RS21365 (4370198) 4370198..4371004 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
N1H43_RS21370 (4371010) 4371010..4371411 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N1H43_RS21375 (4371531) 4371531..4371890 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N1H43_RS21380 (4371887) 4371887..4372117 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
N1H43_RS21385 (4372221) 4372221..4373345 - 1125 WP_001314210.1 ABC transporter permease -
N1H43_RS21390 (4373345) 4373345..4376080 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T257946 WP_042014162.1 NZ_CP104442:c4372117-4371887 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT257946 WP_000593555.1 NZ_CP104442:c4371890-4371531 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References