Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 3606951..3607534 | Replicon | chromosome |
Accession | NZ_CP104442 | ||
Organism | Escherichia coli strain HBUT-L |
Toxin (Protein)
Gene name | mazF | Uniprot ID | S1EZP4 |
Locus tag | N1H43_RS17620 | Protein ID | WP_000254738.1 |
Coordinates | 3606951..3607286 (-) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | N1H43_RS17625 | Protein ID | WP_000581937.1 |
Coordinates | 3607286..3607534 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N1H43_RS17605 (3602838) | 3602838..3604136 | - | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
N1H43_RS17610 (3604224) | 3604224..3605861 | - | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
N1H43_RS17615 (3606089) | 3606089..3606880 | - | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
N1H43_RS17620 (3606951) | 3606951..3607286 | - | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
N1H43_RS17625 (3607286) | 3607286..3607534 | - | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
N1H43_RS17630 (3607612) | 3607612..3609846 | - | 2235 | WP_000226812.1 | GTP diphosphokinase | - |
N1H43_RS17635 (3609894) | 3609894..3611195 | - | 1302 | WP_000046790.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T257942 WP_000254738.1 NZ_CP104442:c3607286-3606951 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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