257935

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2289983..2290509 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N1H43_RS11140 Protein ID WP_000323025.1
Coordinates 2289983..2290270 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N1H43_RS11145 Protein ID WP_000534858.1
Coordinates 2290270..2290509 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS11090 (2285007) 2285007..2285222 - 216 WP_000839590.1 phage lysis protein EssD -
N1H43_RS11095 (2285442) 2285442..2285612 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
N1H43_RS11100 (2285976) 2285976..2286191 - 216 WP_000066484.1 cold shock-like protein CspB -
N1H43_RS11105 (2286492) 2286492..2286704 + 213 WP_000087756.1 cold shock-like protein CspF -
N1H43_RS11110 (2286759) 2286759..2286848 + 90 WP_120795389.1 hypothetical protein -
N1H43_RS11115 (2287126) 2287126..2287878 - 753 WP_001047135.1 antitermination protein -
N1H43_RS11120 (2287892) 2287892..2288941 - 1050 WP_001265199.1 DUF968 domain-containing protein -
N1H43_RS11125 (2288943) 2288943..2289221 - 279 WP_012304870.1 hypothetical protein -
N1H43_RS11130 (2289288) 2289288..2289539 - 252 WP_000980994.1 protein Rem -
N1H43_RS11135 (2289756) 2289756..2289911 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N1H43_RS11140 (2289983) 2289983..2290270 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N1H43_RS11145 (2290270) 2290270..2290509 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N1H43_RS11150 (2290534) 2290534..2290839 + 306 WP_001326990.1 protein YdfV -
N1H43_RS11155 (2291042) 2291042..2291374 + 333 WP_001301033.1 FlxA-like family protein -
N1H43_RS11160 (2291811) 2291811..2291960 - 150 WP_011443592.1 protein YdfW -
N1H43_RS11165 (2292081) 2292081..2293103 - 1023 Protein_2175 ISNCY family transposase -
N1H43_RS11170 (2293893) 2293893..2294180 - 288 Protein_2176 hypothetical protein -
N1H43_RS11175 (2294658) 2294658..2295147 - 490 Protein_2177 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2256013..2309006 52993
- inside Prophage - - 2257455..2309006 51551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T257935 WP_000323025.1 NZ_CP104442:c2290270-2289983 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT257935 WP_000534858.1 NZ_CP104442:c2290509-2290270 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References