257929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1145855..1146473 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N1H43_RS05490 Protein ID WP_001291435.1
Coordinates 1145855..1146073 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N1H43_RS05495 Protein ID WP_000344800.1
Coordinates 1146099..1146473 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS05455 (1141144) 1141144..1141716 + 573 WP_000779826.1 YbaY family lipoprotein -
N1H43_RS05460 (1141747) 1141747..1142058 - 312 WP_000409911.1 MGMT family protein -
N1H43_RS05470 (1142437) 1142437..1142790 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N1H43_RS05475 (1142832) 1142832..1144382 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N1H43_RS05480 (1144546) 1144546..1145016 - 471 WP_000136192.1 YlaC family protein -
N1H43_RS05485 (1145132) 1145132..1145683 - 552 WP_000102564.1 maltose O-acetyltransferase -
N1H43_RS05490 (1145855) 1145855..1146073 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N1H43_RS05495 (1146099) 1146099..1146473 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N1H43_RS05500 (1147019) 1147019..1150168 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N1H43_RS05505 (1150191) 1150191..1151384 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257929 WP_001291435.1 NZ_CP104442:c1146073-1145855 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257929 WP_000344800.1 NZ_CP104442:c1146473-1146099 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References