257925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 531640..532975 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name sanaT Uniprot ID E0J2C5
Locus tag N1H43_RS02520 Protein ID WP_000342500.1
Coordinates 532028..532975 (+) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag N1H43_RS02515 Protein ID WP_000152741.1
Coordinates 531640..532035 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS02485 (527405) 527405..528358 + 954 WP_000290405.1 hypothetical protein -
N1H43_RS02490 (528594) 528594..529412 + 819 WP_000761991.1 DUF932 domain-containing protein -
N1H43_RS02495 (529442) 529442..529915 + 474 WP_001292742.1 DNA repair protein RadC -
N1H43_RS02500 (529915) 529915..530250 + 336 WP_000939438.1 type IV toxin-antitoxin system YeeU family antitoxin -
N1H43_RS02505 (530281) 530281..530622 + 342 WP_000691790.1 TA system toxin CbtA family protein -
N1H43_RS02510 (530737) 530737..531570 + 834 WP_001192746.1 DUF4942 domain-containing protein -
N1H43_RS02515 (531640) 531640..532035 + 396 WP_000152741.1 DUF6088 family protein Antitoxin
N1H43_RS02520 (532028) 532028..532975 + 948 WP_000342500.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N1H43_RS02525 (533368) 533368..534633 + 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
N1H43_RS02530 (534834) 534834..536303 - 1470 WP_001022619.1 serine/threonine-protein kinase -
N1H43_RS02535 (536300) 536300..536842 - 543 WP_001115385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 514323..563316 48993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35562.71 Da        Isoelectric Point: 4.9737

>T257925 WP_000342500.1 NZ_CP104442:532028-532975 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGSTGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT257925 WP_000152741.1 NZ_CP104442:531640-532035 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J2C5

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References