Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 529915..530622 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name ykfI Uniprot ID E0J2C8
Locus tag N1H43_RS02505 Protein ID WP_000691790.1
Coordinates 530281..530622 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N1H43_RS02500 Protein ID WP_000939438.1
Coordinates 529915..530250 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS02475 (525862) 525862..526080 - 219 WP_001064742.1 AlpA family phage regulatory protein -
N1H43_RS02480 (526198) 526198..526812 - 615 WP_000772909.1 inovirus Gp2 family protein -
N1H43_RS02485 (527405) 527405..528358 + 954 WP_000290405.1 hypothetical protein -
N1H43_RS02490 (528594) 528594..529412 + 819 WP_000761991.1 DUF932 domain-containing protein -
N1H43_RS02495 (529442) 529442..529915 + 474 WP_001292742.1 DNA repair protein RadC -
N1H43_RS02500 (529915) 529915..530250 + 336 WP_000939438.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N1H43_RS02505 (530281) 530281..530622 + 342 WP_000691790.1 TA system toxin CbtA family protein Toxin
N1H43_RS02510 (530737) 530737..531570 + 834 WP_001192746.1 DUF4942 domain-containing protein -
N1H43_RS02515 (531640) 531640..532035 + 396 WP_000152741.1 DUF6088 family protein -
N1H43_RS02520 (532028) 532028..532975 + 948 WP_000342500.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
N1H43_RS02525 (533368) 533368..534633 + 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 514323..563316 48993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13060.08 Da        Isoelectric Point: 9.4583

>T257924 WP_000691790.1 NZ_CP104442:530281-530622 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCYNTTAR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12639.63 Da        Isoelectric Point: 7.7723

>AT257924 WP_000939438.1 NZ_CP104442:529915-530250 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPWQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J2C8

Antitoxin

Source ID Structure

References