257923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 461287..461882 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N1H43_RS02175 Protein ID WP_000239579.1
Coordinates 461532..461882 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N1H43_RS02170 Protein ID WP_001223208.1
Coordinates 461287..461538 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS02160 (456951) 456951..460730 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
N1H43_RS02165 (460733) 460733..461074 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N1H43_RS02170 (461287) 461287..461538 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N1H43_RS02175 (461532) 461532..461882 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N1H43_RS02180 (461962) 461962..462492 - 531 WP_000055072.1 inorganic diphosphatase -
N1H43_RS02185 (462802) 462802..463758 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N1H43_RS02190 (463898) 463898..465400 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
N1H43_RS02195 (465414) 465414..466436 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T257923 WP_000239579.1 NZ_CP104442:461532-461882 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT257923 WP_001223208.1 NZ_CP104442:461287-461538 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References