Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4760900..4761516 Replicon chromosome
Accession NZ_CP104405
Organism Enterobacter hormaechei subsp. steigerwaltii strain 4236

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5F16_RS22975 Protein ID WP_017382676.1
Coordinates 4760900..4761271 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag N5F16_RS22980 Protein ID WP_015569912.1
Coordinates 4761274..4761516 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F16_RS22960 (N5F16_22960) 4758400..4759302 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
N5F16_RS22965 (N5F16_22965) 4759299..4759934 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
N5F16_RS22970 (N5F16_22970) 4759931..4760860 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
N5F16_RS22975 (N5F16_22975) 4760900..4761271 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
N5F16_RS22980 (N5F16_22980) 4761274..4761516 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
N5F16_RS22985 (N5F16_22985) 4761715..4762635 + 921 WP_133983330.1 alpha/beta hydrolase -
N5F16_RS22990 (N5F16_22990) 4762644..4763585 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
N5F16_RS22995 (N5F16_22995) 4763630..4764067 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
N5F16_RS23000 (N5F16_23000) 4764064..4764945 - 882 WP_003861949.1 virulence factor BrkB family protein -
N5F16_RS23005 (N5F16_23005) 4764939..4765538 - 600 WP_133983332.1 glucose-1-phosphatase -
N5F16_RS23010 (N5F16_23010) 4765657..4766457 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T257916 WP_017382676.1 NZ_CP104405:c4761271-4760900 [Enterobacter hormaechei subsp. steigerwaltii]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT257916 WP_015569912.1 NZ_CP104405:c4761516-4761274 [Enterobacter hormaechei subsp. steigerwaltii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References