Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3864873..3865530 Replicon chromosome
Accession NZ_CP104405
Organism Enterobacter hormaechei subsp. steigerwaltii strain 4236

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag N5F16_RS18590 Protein ID WP_017382887.1
Coordinates 3864873..3865283 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag N5F16_RS18595 Protein ID WP_003863437.1
Coordinates 3865264..3865530 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F16_RS18570 (N5F16_18570) 3860871..3862604 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
N5F16_RS18575 (N5F16_18575) 3862610..3863323 - 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5F16_RS18580 (N5F16_18580) 3863352..3864248 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
N5F16_RS18585 (N5F16_18585) 3864350..3864871 + 522 WP_015571793.1 flavodoxin FldB -
N5F16_RS18590 (N5F16_18590) 3864873..3865283 - 411 WP_017382887.1 protein YgfX Toxin
N5F16_RS18595 (N5F16_18595) 3865264..3865530 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
N5F16_RS18600 (N5F16_18600) 3865825..3866805 + 981 WP_047636517.1 tRNA-modifying protein YgfZ -
N5F16_RS18605 (N5F16_18605) 3866917..3867576 - 660 WP_003863433.1 hemolysin III family protein -
N5F16_RS18610 (N5F16_18610) 3867843..3868574 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
N5F16_RS18615 (N5F16_18615) 3868691..3869152 + 462 Protein_3635 family 1 glycosylhydrolase -
N5F16_RS18620 (N5F16_18620) 3869207..3869911 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
N5F16_RS18625 (N5F16_18625) 3869978..3870211 - 234 Protein_3637 protein-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T257915 WP_017382887.1 NZ_CP104405:c3865283-3864873 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT257915 WP_003863437.1 NZ_CP104405:c3865530-3865264 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References