Detailed information of TA system TA025791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 411160..412745
• Replicon: chromosome
• Accession: NC_016745
• Organism: Oceanimonas sp. GK1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: H2FYZ2
• Locus tag: GU3_RS02030
• Protein ID: WP_014290893.1
• Coordinates: 411426..412745 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GU3_RS02025
• Protein ID: WP_014290892.1
• Coordinates: 411160..411426 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GU3_RS02000	406928..407062	+	135	WP_014290886.1	50S ribosomal protein L34	-
GU3_RS02005	407062..407424	+	363	WP_014290887.1	ribonuclease P protein component	-
GU3_RS16685	407385..407630	+	246	WP_014290888.1	membrane protein insertion efficiency factor YidD	-
GU3_RS02010	407635..409296	+	1662	WP_014290889.1	membrane protein insertase YidC	-
GU3_RS02015	409418..410779	+	1362	WP_014290890.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
GU3_RS02020	410801..411019	+	219	WP_014290891.1	hypothetical protein	-
GU3_RS02025	411160..411426	+	267	WP_014290892.1	helix-turn-helix domain-containing protein	Antitoxin
GU3_RS02030	411426..412745	+	1320	WP_014290893.1	type II toxin-antitoxin system HipA family toxin	Toxin
GU3_RS02035	412867..414504	+	1638	WP_014290894.1	methyl-accepting chemotaxis protein	-
GU3_RS02040	414543..415589	-	1047	WP_014290895.1	alkene reductase	-
GU3_RS02045	415733..416314	+	582	WP_014290896.1	TetR/AcrR family transcriptional regulator	-
GU3_RS02050	416340..417176	-	837	WP_014290897.1	metal ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 48918.17 Da
• Isoelectric Point: 8.8834

>T25791 WP_014290893.1 NC_016745:411426-412745 [Oceanimonas sp. GK1]
MAALDVYMNGYRVGVFTRTGSGAHHFKYNEAWLRLPGSRPISLSMPLRHQTYQGSEAYNFFDNLLPDTPDVRNRILARYH
ANSTQPFDLLSKVGADTVGALQLLPQGIPPGDIRKMEYKVLSDKELEKVLTGYQAGAPLGMIEEAKDFRISIAGAQEKTA
LLLLGDKWCQPRNATPTTHIIKLPIGRIESHSYAIDLSDSVENEYLCTLLAREFGLPVPTCFMMQVGSIKALAVERFDRK
YASDGSWLMRLPQEDFCQVLNVPSARKYETHGGPGIAEIMSYLLGSANAEQDRYRFMKAQVLFWLLAATDGHAKNFSVFI
ESDGRFRLTPFYDILSMYPVFGGRGLHPRDAKLAMGLKGTKGRKYGIEQIFPRHFFQTAKAVGFSQEAMATILAEVAGSV
DTAIDKVSKQLPNDFPVHIRDSILEGVKARSARLTPGRD

Nucleotide

• Length: 1320 bp

>T25791 NC_016745:411426-412745 [Oceanimonas sp. GK1]
ATGGCAGCGCTGGATGTCTACATGAACGGTTACCGGGTGGGCGTTTTCACCCGAACCGGCTCAGGTGCCCATCACTTCAA
ATACAACGAGGCCTGGCTACGCTTGCCAGGAAGCCGTCCGATATCACTGTCCATGCCACTGCGTCATCAGACGTATCAAG
GGAGTGAAGCATACAACTTCTTTGACAACCTGTTACCTGATACGCCTGACGTCAGGAACCGGATCCTTGCCAGATACCAC
GCAAACTCAACCCAACCTTTCGATTTGCTGTCCAAGGTCGGGGCCGACACTGTGGGTGCCCTGCAACTGTTGCCCCAAGG
CATTCCCCCCGGCGATATTCGAAAAATGGAATACAAGGTGTTGTCCGACAAAGAGCTGGAAAAAGTGCTGACCGGCTATC
AGGCGGGTGCTCCTCTGGGGATGATCGAGGAAGCAAAAGACTTTCGGATTTCCATCGCCGGTGCCCAGGAGAAAACGGCA
CTGCTGCTCCTGGGGGATAAATGGTGCCAGCCCCGTAATGCCACACCAACAACCCATATCATCAAGCTGCCTATCGGCAG
GATAGAAAGCCACTCATACGCCATTGACCTGTCCGACAGTGTCGAAAACGAGTATCTCTGTACCTTGCTGGCACGAGAGT
TTGGATTGCCGGTGCCCACCTGCTTCATGATGCAGGTGGGCAGCATCAAGGCTCTGGCTGTTGAGCGTTTTGACCGTAAA
TATGCATCGGATGGCAGCTGGCTTATGCGCTTGCCGCAGGAGGACTTTTGCCAGGTACTGAACGTCCCATCGGCACGGAA
GTACGAGACTCATGGTGGACCAGGCATTGCAGAGATCATGTCCTACCTGCTGGGCTCGGCCAATGCCGAGCAAGACCGCT
ATCGGTTCATGAAAGCACAGGTATTGTTTTGGCTGCTGGCCGCAACAGATGGCCATGCCAAGAACTTTTCCGTGTTCATT
GAGTCCGATGGCCGCTTTCGCCTGACCCCTTTCTACGACATTCTTTCCATGTACCCGGTGTTTGGTGGCAGAGGTCTTCA
TCCACGCGATGCCAAACTGGCCATGGGTCTCAAAGGTACGAAAGGCAGGAAGTACGGCATTGAGCAAATCTTTCCAAGAC
ACTTCTTCCAGACAGCCAAAGCAGTAGGCTTTTCTCAGGAGGCTATGGCGACCATTCTGGCGGAAGTAGCAGGCTCGGTT
GATACTGCCATCGACAAGGTCAGCAAGCAGTTGCCAAACGACTTCCCCGTTCACATTCGTGATTCAATACTGGAAGGGGT
AAAAGCCAGATCTGCCCGGCTGACGCCCGGCAGAGATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9715.04 Da
• Isoelectric Point: 8.6222

>AT25791 WP_014290892.1 NC_016745:411160-411426 [Oceanimonas sp. GK1]
MKITSAHQLSAYMKDVRLTQKLSQGKVAGKVGIRQDTVSNFELHPDTTKLETLFKILSALELELTVQPRNTTGADAGNNA
SAGWKEEW

Nucleotide

• Length: 267 bp

>AT25791 NC_016745:411160-411426 [Oceanimonas sp. GK1]
ATGAAAATCACTAGTGCCCATCAGCTCAGCGCTTACATGAAAGATGTCAGGCTCACCCAGAAGCTTTCCCAGGGTAAGGT
GGCCGGCAAAGTGGGGATCCGGCAGGACACGGTTTCCAACTTTGAACTGCACCCGGATACCACCAAACTGGAGACCTTAT
TCAAGATCCTGTCGGCATTGGAGCTGGAGCTGACGGTTCAGCCACGAAATACCACTGGCGCAGACGCAGGTAACAATGCA
TCTGCAGGCTGGAAGGAAGAGTGGTAA

Structures

Toxin

• AlphaFold DB: H2FYZ2