Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1773057..1773854 Replicon chromosome
Accession NZ_CP104405
Organism Enterobacter hormaechei subsp. steigerwaltii strain 4236

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag N5F16_RS08480 Protein ID WP_133982579.1
Coordinates 1773333..1773854 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag N5F16_RS08475 Protein ID WP_015570876.1
Coordinates 1773057..1773326 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F16_RS08440 (N5F16_08440) 1768596..1768955 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
N5F16_RS08445 (N5F16_08445) 1769034..1769129 - 96 Protein_1638 transcriptional regulator -
N5F16_RS08450 (N5F16_08450) 1769284..1770525 + 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
N5F16_RS08455 (N5F16_08455) 1770558..1770785 - 228 WP_006809324.1 YccJ family protein -
N5F16_RS08460 (N5F16_08460) 1770804..1771400 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
N5F16_RS08465 (N5F16_08465) 1771791..1771961 + 171 WP_001273664.1 general stress protein -
N5F16_RS08470 (N5F16_08470) 1772078..1772983 + 906 WP_032653183.1 DMT family transporter -
N5F16_RS08475 (N5F16_08475) 1773057..1773326 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
N5F16_RS08480 (N5F16_08480) 1773333..1773854 + 522 WP_133982579.1 GNAT family N-acetyltransferase Toxin
N5F16_RS08485 (N5F16_08485) 1773913..1775235 - 1323 WP_133982581.1 pyrimidine utilization transport protein G -
N5F16_RS08490 (N5F16_08490) 1775257..1775748 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
N5F16_RS08495 (N5F16_08495) 1775761..1776351 - 591 WP_032619952.1 malonic semialdehyde reductase -
N5F16_RS08500 (N5F16_08500) 1776361..1777161 - 801 WP_126291284.1 pyrimidine utilization protein D -
N5F16_RS08505 (N5F16_08505) 1777169..1777555 - 387 WP_133982582.1 pyrimidine utilization protein C -
N5F16_RS08510 (N5F16_08510) 1777567..1778256 - 690 WP_045338811.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19479.26 Da        Isoelectric Point: 7.4318

>T257906 WP_133982579.1 NZ_CP104405:1773333-1773854 [Enterobacter hormaechei subsp. steigerwaltii]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKVMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT257906 WP_015570876.1 NZ_CP104405:1773057-1773326 [Enterobacter hormaechei subsp. steigerwaltii]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References