Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4764734..4765350 Replicon chromosome
Accession NZ_CP104403
Organism Enterobacter hormaechei subsp. steigerwaltii strain csa13R

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5F14_RS23055 Protein ID WP_017382676.1
Coordinates 4764734..4765105 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag N5F14_RS23060 Protein ID WP_015569912.1
Coordinates 4765108..4765350 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F14_RS23040 (N5F14_23040) 4762234..4763136 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
N5F14_RS23045 (N5F14_23045) 4763133..4763768 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
N5F14_RS23050 (N5F14_23050) 4763765..4764694 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
N5F14_RS23055 (N5F14_23055) 4764734..4765105 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
N5F14_RS23060 (N5F14_23060) 4765108..4765350 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
N5F14_RS23065 (N5F14_23065) 4765549..4766469 + 921 WP_133983330.1 alpha/beta hydrolase -
N5F14_RS23070 (N5F14_23070) 4766478..4767419 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
N5F14_RS23075 (N5F14_23075) 4767464..4767901 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
N5F14_RS23080 (N5F14_23080) 4767898..4768779 - 882 WP_003861949.1 virulence factor BrkB family protein -
N5F14_RS23085 (N5F14_23085) 4768773..4769372 - 600 WP_133983332.1 glucose-1-phosphatase -
N5F14_RS23090 (N5F14_23090) 4769491..4770291 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T257897 WP_017382676.1 NZ_CP104403:c4765105-4764734 [Enterobacter hormaechei subsp. steigerwaltii]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT257897 WP_015569912.1 NZ_CP104403:c4765350-4765108 [Enterobacter hormaechei subsp. steigerwaltii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References