Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3868697..3869354 Replicon chromosome
Accession NZ_CP104403
Organism Enterobacter hormaechei subsp. steigerwaltii strain csa13R

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag N5F14_RS18670 Protein ID WP_017382887.1
Coordinates 3868697..3869107 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag N5F14_RS18675 Protein ID WP_003863437.1
Coordinates 3869088..3869354 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F14_RS18650 (N5F14_18650) 3864695..3866428 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
N5F14_RS18655 (N5F14_18655) 3866434..3867147 - 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5F14_RS18660 (N5F14_18660) 3867176..3868072 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
N5F14_RS18665 (N5F14_18665) 3868174..3868695 + 522 WP_015571793.1 flavodoxin FldB -
N5F14_RS18670 (N5F14_18670) 3868697..3869107 - 411 WP_017382887.1 protein YgfX Toxin
N5F14_RS18675 (N5F14_18675) 3869088..3869354 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
N5F14_RS18680 (N5F14_18680) 3869649..3870629 + 981 WP_047636517.1 tRNA-modifying protein YgfZ -
N5F14_RS18685 (N5F14_18685) 3870741..3871400 - 660 WP_003863433.1 hemolysin III family protein -
N5F14_RS18690 (N5F14_18690) 3871667..3872398 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
N5F14_RS18695 (N5F14_18695) 3872515..3872976 + 462 Protein_3651 family 1 glycosylhydrolase -
N5F14_RS18700 (N5F14_18700) 3873031..3873735 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
N5F14_RS18705 (N5F14_18705) 3873802..3874035 - 234 Protein_3653 protein-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T257896 WP_017382887.1 NZ_CP104403:c3869107-3868697 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT257896 WP_003863437.1 NZ_CP104403:c3869354-3869088 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References