Detailed information of TA system TA025789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 696914..697532
• Replicon: chromosome
• Accession: NC_016645
• Organism: Pyrobaculum sp. 1860

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: P186_RS03810
• Protein ID: WP_014288084.1
• Coordinates: 697134..697532 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: P186_RS03805
• Protein ID: WP_014288083.1
• Coordinates: 696914..697150 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P186_RS03780 (P186_0805)	692922..693860	+	939	WP_014288079.1	pyridoxal phosphate-dependent aminotransferase	-
P186_RS03785 (P186_0806)	693857..694483	+	627	WP_014288080.1	RNA 2'-phosphotransferase	-
P186_RS03790 (P186_0807)	694495..695397	-	903	WP_014288081.1	hypothetical protein	-
P186_RS03795 (P186_0808)	695482..696135	+	654	WP_237179459.1	IclR family transcriptional regulator	-
P186_RS14230	696051..696353	+	303	WP_237179460.1	helix-turn-helix domain-containing protein	-
P186_RS03800 (P186_0810)	696391..696681	+	291	WP_014288082.1	GYD domain-containing protein	-
P186_RS03805 (P186_0811)	696914..697150	+	237	WP_014288083.1	hypothetical protein	Antitoxin
P186_RS03810 (P186_0812)	697134..697532	+	399	WP_014288084.1	type II toxin-antitoxin system VapC family toxin	Toxin
P186_RS03815 (P186_0813)	697709..698302	+	594	WP_014288085.1	hypothetical protein	-
P186_RS03820 (P186_0815)	699015..699866	+	852	WP_014288087.1	hypothetical protein	-
P186_RS03825 (P186_0816)	699895..700377	+	483	WP_014288088.1	hypothetical protein	-
P186_RS03830 (P186_0817)	700379..701293	+	915	WP_148682691.1	MBL fold metallo-hydrolase	-
P186_RS03835 (P186_0818)	701340..701789	-	450	WP_014288090.1	PIN domain-containing protein	-
P186_RS03840 (P186_0819)	701758..702006	-	249	WP_148682692.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (4-124)

Antitoxin

• Putative antitoxin VapB3-like (2-75)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14483.85 Da
• Isoelectric Point: 4.7503

>T25789 WP_014288084.1 NC_016645:697134-697532 [Pyrobaculum ferrireducens]
MRIVADASAIAALYLPEKLSEEVEKALAGADSVSSLDLAAYEVLNVVWKRARRGLISREAALEIAGEVLQLFKTLEVYSY
REVLPDALEIALERGVTVYDSAYVALAKKLGATLLTLDKQIAQAFPQIVYRL

Nucleotide

• Length: 399 bp

>T25789 NC_016645:697134-697532 [Pyrobaculum ferrireducens]
ATGCGGATAGTCGCTGATGCCTCGGCGATCGCCGCTCTGTACCTGCCGGAGAAGCTGAGTGAAGAGGTGGAGAAGGCACT
AGCCGGGGCCGACTCAGTCTCTTCGCTTGACTTAGCGGCGTACGAGGTCCTCAACGTGGTGTGGAAACGCGCCAGGCGGG
GCCTCATAAGCCGGGAGGCGGCTCTCGAAATCGCGGGGGAGGTGCTTCAGCTATTTAAAACCTTGGAGGTGTACAGCTAT
AGGGAGGTCCTCCCCGACGCCCTAGAAATAGCCCTGGAGAGGGGAGTCACGGTGTACGACTCGGCATATGTAGCCCTAGC
TAAAAAACTAGGCGCAACCCTCCTGACGCTCGACAAACAAATCGCTCAAGCCTTCCCCCAGATTGTCTACAGGCTGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9231.54 Da
• Isoelectric Point: 9.7682

>AT25789 WP_014288083.1 NC_016645:696914-697150 [Pyrobaculum ferrireducens]
VSDVISVRVRKELKKALEDLGIDYAEEVRRYLEELVARERRRRALERARQLRKTLEREVGVLPTAAELIREDRDADSR

Nucleotide

• Length: 237 bp

>AT25789 NC_016645:696914-697150 [Pyrobaculum ferrireducens]
GTGAGTGATGTCATATCTGTGAGAGTTAGAAAGGAGCTGAAGAAGGCGCTGGAGGATCTGGGTATTGACTACGCAGAGGA
GGTCCGGCGTTATCTAGAGGAGCTGGTGGCTAGGGAGAGGAGGAGAAGGGCCTTGGAGAGGGCCCGCCAGCTACGGAAAA
CTCTGGAGAGGGAGGTCGGCGTCTTGCCTACCGCGGCTGAGCTGATTAGGGAGGATAGGGATGCGGATAGTCGCTGA