Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2364313..2365052 Replicon chromosome
Accession NZ_CP104403
Organism Enterobacter hormaechei subsp. steigerwaltii strain csa13R

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag N5F14_RS11525 Protein ID WP_003857133.1
Coordinates 2364313..2364798 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag N5F14_RS11530 Protein ID WP_003857131.1
Coordinates 2364786..2365052 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F14_RS11500 (N5F14_11500) 2359847..2360431 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
N5F14_RS11505 (N5F14_11505) 2360518..2361276 + 759 WP_045341969.1 DeoR/GlpR family DNA-binding transcription regulator -
N5F14_RS11510 (N5F14_11510) 2361381..2362673 + 1293 WP_133982766.1 glycosyl hydrolase family 28 protein -
N5F14_RS11515 (N5F14_11515) 2362919..2363677 + 759 WP_230016020.1 hypothetical protein -
N5F14_RS11520 (N5F14_11520) 2363693..2364262 + 570 WP_017382346.1 hypothetical protein -
N5F14_RS11525 (N5F14_11525) 2364313..2364798 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
N5F14_RS11530 (N5F14_11530) 2364786..2365052 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
N5F14_RS11535 (N5F14_11535) 2365116..2366045 - 930 WP_133982768.1 LysR family transcriptional regulator -
N5F14_RS11540 (N5F14_11540) 2366175..2367557 + 1383 WP_062938939.1 MFS transporter -
N5F14_RS11545 (N5F14_11545) 2367580..2368575 - 996 WP_045339807.1 DUF2891 domain-containing protein -
N5F14_RS11550 (N5F14_11550) 2368585..2369571 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T257888 WP_003857133.1 NZ_CP104403:c2364798-2364313 [Enterobacter hormaechei subsp. steigerwaltii]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT257888 WP_003857131.1 NZ_CP104403:c2365052-2364786 [Enterobacter hormaechei subsp. steigerwaltii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References