Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1744321..1745118 Replicon chromosome
Accession NZ_CP104403
Organism Enterobacter hormaechei subsp. steigerwaltii strain csa13R

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag N5F14_RS08345 Protein ID WP_133982579.1
Coordinates 1744597..1745118 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag N5F14_RS08340 Protein ID WP_015570876.1
Coordinates 1744321..1744590 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F14_RS08305 (N5F14_08305) 1739860..1740219 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
N5F14_RS08310 (N5F14_08310) 1740298..1740393 - 96 Protein_1611 transcriptional regulator -
N5F14_RS08315 (N5F14_08315) 1740548..1741789 + 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
N5F14_RS08320 (N5F14_08320) 1741822..1742049 - 228 WP_006809324.1 YccJ family protein -
N5F14_RS08325 (N5F14_08325) 1742068..1742664 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
N5F14_RS08330 (N5F14_08330) 1743055..1743225 + 171 WP_001273664.1 general stress protein -
N5F14_RS08335 (N5F14_08335) 1743342..1744247 + 906 WP_032653183.1 DMT family transporter -
N5F14_RS08340 (N5F14_08340) 1744321..1744590 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
N5F14_RS08345 (N5F14_08345) 1744597..1745118 + 522 WP_133982579.1 GNAT family N-acetyltransferase Toxin
N5F14_RS08350 (N5F14_08350) 1745177..1746499 - 1323 WP_133982581.1 pyrimidine utilization transport protein G -
N5F14_RS08355 (N5F14_08355) 1746521..1747012 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
N5F14_RS08360 (N5F14_08360) 1747025..1747615 - 591 WP_032619952.1 malonic semialdehyde reductase -
N5F14_RS08365 (N5F14_08365) 1747625..1748425 - 801 WP_126291284.1 pyrimidine utilization protein D -
N5F14_RS08370 (N5F14_08370) 1748433..1748819 - 387 WP_133982582.1 pyrimidine utilization protein C -
N5F14_RS08375 (N5F14_08375) 1748831..1749520 - 690 WP_045338811.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19479.26 Da        Isoelectric Point: 7.4318

>T257887 WP_133982579.1 NZ_CP104403:1744597-1745118 [Enterobacter hormaechei subsp. steigerwaltii]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKVMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT257887 WP_015570876.1 NZ_CP104403:1744321-1744590 [Enterobacter hormaechei subsp. steigerwaltii]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References