Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2393049..2393788 Replicon chromosome
Accession NZ_CP104401
Organism Enterobacter hormaechei subsp. steigerwaltii strain colR

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag N5F15_RS11665 Protein ID WP_003857133.1
Coordinates 2393049..2393534 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag N5F15_RS11670 Protein ID WP_003857131.1
Coordinates 2393522..2393788 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F15_RS11640 (N5F15_11640) 2388583..2389167 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
N5F15_RS11645 (N5F15_11645) 2389254..2390012 + 759 WP_045341969.1 DeoR/GlpR family DNA-binding transcription regulator -
N5F15_RS11650 (N5F15_11650) 2390117..2391409 + 1293 WP_133982766.1 glycosyl hydrolase family 28 protein -
N5F15_RS11655 (N5F15_11655) 2391655..2392413 + 759 WP_230016020.1 hypothetical protein -
N5F15_RS11660 (N5F15_11660) 2392429..2392998 + 570 WP_017382346.1 hypothetical protein -
N5F15_RS11665 (N5F15_11665) 2393049..2393534 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
N5F15_RS11670 (N5F15_11670) 2393522..2393788 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
N5F15_RS11675 (N5F15_11675) 2393852..2394781 - 930 WP_133982768.1 LysR family transcriptional regulator -
N5F15_RS11680 (N5F15_11680) 2394911..2396293 + 1383 WP_062938939.1 MFS transporter -
N5F15_RS11685 (N5F15_11685) 2396316..2397311 - 996 WP_045339807.1 DUF2891 domain-containing protein -
N5F15_RS11690 (N5F15_11690) 2397321..2398307 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T257870 WP_003857133.1 NZ_CP104401:c2393534-2393049 [Enterobacter hormaechei subsp. steigerwaltii]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT257870 WP_003857131.1 NZ_CP104401:c2393788-2393522 [Enterobacter hormaechei subsp. steigerwaltii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References