Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 298446..299042 Replicon chromosome
Accession NZ_CP104401
Organism Enterobacter hormaechei subsp. steigerwaltii strain colR

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag N5F15_RS01430 Protein ID WP_023315213.1
Coordinates 298740..299042 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag N5F15_RS01425 Protein ID WP_032672198.1
Coordinates 298446..298733 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F15_RS01420 (N5F15_01420) 296818..298449 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
N5F15_RS01425 (N5F15_01425) 298446..298733 - 288 WP_032672198.1 putative addiction module antidote protein Antitoxin
N5F15_RS01430 (N5F15_01430) 298740..299042 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5F15_RS01435 (N5F15_01435) 299240..300112 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
N5F15_RS01440 (N5F15_01440) 300113..300385 - 273 WP_017382612.1 DUF3811 domain-containing protein -
N5F15_RS01445 (N5F15_01445) 300436..301380 - 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
N5F15_RS01450 (N5F15_01450) 301474..302823 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T257863 WP_023315213.1 NZ_CP104401:c299042-298740 [Enterobacter hormaechei subsp. steigerwaltii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10088.51 Da        Isoelectric Point: 4.7045

>AT257863 WP_032672198.1 NZ_CP104401:c298733-298446 [Enterobacter hormaechei subsp. steigerwaltii]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAEALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure

References