Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpB-pemI/PRK09812-MazE
Location 29179..29780 Replicon plasmid pHG52
Accession NZ_CP104394
Organism Enterococcus raffinosus strain HG-5

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag N4S13_RS21520 Protein ID WP_244299263.1
Coordinates 29439..29780 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A4V1ENG6
Locus tag N4S13_RS21515 Protein ID WP_070621550.1
Coordinates 29179..29439 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4S13_RS21490 (N4S13_21490) 24422..25462 + 1041 WP_070503196.1 replication initiator protein A -
N4S13_RS21495 (N4S13_21495) 25541..26266 + 726 WP_070503194.1 hypothetical protein -
N4S13_RS21500 (N4S13_21500) 27390..27731 + 342 WP_070504146.1 type IV conjugative transfer system protein TraE -
N4S13_RS21505 (N4S13_21505) 28423..28629 + 207 WP_137438795.1 hypothetical protein -
N4S13_RS21510 (N4S13_21510) 28671..28844 + 174 WP_185939400.1 hypothetical protein -
N4S13_RS21515 (N4S13_21515) 29179..29439 + 261 WP_070621550.1 toxin-antitoxin system, antitoxin component, AbrB family protein Antitoxin
N4S13_RS21520 (N4S13_21520) 29439..29780 + 342 WP_244299263.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N4S13_RS21525 (N4S13_21525) 29800..31152 + 1353 WP_070503788.1 C39 family peptidase -
N4S13_RS21530 (N4S13_21530) 31176..31901 + 726 WP_070503791.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) - 1..79977 79977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13110.31 Da        Isoelectric Point: 6.8620

>T257861 WP_244299263.1 NZ_CP104394:29439-29780 [Enterococcus raffinosus]
VVEKKIFSDLQQGDILFLDFDPTKGHEQRGYRPCIVLTKSIRFLNYMFGVAPITSNSRSFPLHIPLPETMEVKGNVLLEH
HRMVDLETRTFKFVETAPPEFIEECVAKLKLLY

Download         Length: 342 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9575.98 Da        Isoelectric Point: 4.4563

>AT257861 WP_070621550.1 NZ_CP104394:29179-29439 [Enterococcus raffinosus]
MLIKDTELKTWGNSKALRIGKDELAALGLSDKQLAITLIVENGKITIVPKTKYPQTLDELFAGYDGAALTPDDRYEWDEP
VGREII

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1ENG6

References