Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 543933..544569 Replicon chromosome
Accession NZ_CP104391
Organism Bacillus safensis strain GX-H6

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag N4Q31_RS02620 Protein ID WP_024425388.1
Coordinates 544219..544569 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag N4Q31_RS02615 Protein ID WP_003214273.1
Coordinates 543933..544214 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4Q31_RS02595 (N4Q31_02595) 540072..540677 - 606 WP_039176707.1 rhomboid family intramembrane serine protease -
N4Q31_RS02600 (N4Q31_02600) 540773..541138 + 366 WP_039176708.1 holo-ACP synthase -
N4Q31_RS02605 (N4Q31_02605) 541299..542315 + 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
N4Q31_RS02610 (N4Q31_02610) 542457..543638 + 1182 WP_260775330.1 alanine racemase -
N4Q31_RS02615 (N4Q31_02615) 543933..544214 + 282 WP_003214273.1 hypothetical protein Antitoxin
N4Q31_RS02620 (N4Q31_02620) 544219..544569 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
N4Q31_RS02625 (N4Q31_02625) 544686..545516 + 831 WP_039176712.1 RsbT co-antagonist protein RsbRA -
N4Q31_RS02630 (N4Q31_02630) 545521..545889 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
N4Q31_RS02635 (N4Q31_02635) 545892..546293 + 402 WP_024425390.1 anti-sigma regulatory factor -
N4Q31_RS02640 (N4Q31_02640) 546304..547311 + 1008 WP_039176714.1 PP2C family protein-serine/threonine phosphatase -
N4Q31_RS02645 (N4Q31_02645) 547371..547700 + 330 WP_024425392.1 anti-sigma factor antagonist -
N4Q31_RS02650 (N4Q31_02650) 547697..548185 + 489 WP_003214356.1 anti-sigma B factor RsbW -
N4Q31_RS02655 (N4Q31_02655) 548151..548939 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
N4Q31_RS02660 (N4Q31_02660) 548939..549538 + 600 WP_039176718.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T257858 WP_024425388.1 NZ_CP104391:544219-544569 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT257858 WP_003214273.1 NZ_CP104391:543933-544214 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References