257854

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2342902..2343534 Replicon chromosome
Accession NZ_CP104386
Organism Cupriavidus gilardii strain WM02

Toxin (Protein)


Gene name hicA Uniprot ID A0A0M5KT30
Locus tag N4G38_RS10990 Protein ID WP_053821538.1
Coordinates 2342902..2343078 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4G38_RS10995 Protein ID WP_260730444.1
Coordinates 2343118..2343534 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G38_RS10965 (N4G38_10965) 2338250..2338750 + 501 WP_023264649.1 peptidylprolyl isomerase -
N4G38_RS10970 (N4G38_10970) 2338867..2339649 + 783 WP_260730442.1 UDP-2,3-diacylglucosamine diphosphatase -
N4G38_RS10975 (N4G38_10975) 2339700..2340443 - 744 WP_174105791.1 serine O-acetyltransferase -
N4G38_RS10980 (N4G38_10980) 2340804..2341724 - 921 WP_260730443.1 RNA methyltransferase -
N4G38_RS10985 (N4G38_10985) 2341917..2342735 + 819 WP_064573223.1 inositol monophosphatase family protein -
N4G38_RS10990 (N4G38_10990) 2342902..2343078 + 177 WP_053821538.1 type II toxin-antitoxin system HicA family toxin Toxin
N4G38_RS10995 (N4G38_10995) 2343118..2343534 + 417 WP_260730444.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4G38_RS11000 (N4G38_11000) 2343724..2346393 + 2670 WP_082371422.1 DNA mismatch repair protein MutS -
N4G38_RS11005 (N4G38_11005) 2346390..2347469 + 1080 WP_260730445.1 hypothetical protein -
N4G38_RS11010 (N4G38_11010) 2347545..2348072 - 528 WP_006576455.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6588.65 Da        Isoelectric Point: 11.9145

>T257854 WP_053821538.1 NZ_CP104386:2342902-2343078 [Cupriavidus gilardii]
VKQSEFRRWLGRQGATFADGGKHLKVYLNGRQSTMPRHPGKEIAERTRKAILKQLGLA

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15361.59 Da        Isoelectric Point: 4.3793

>AT257854 WP_260730444.1 NZ_CP104386:2343118-2343534 [Cupriavidus gilardii]
MLRYPVILTADDDGVAVSFPDIPEALTCGDSHEEALQMAADALVTAMEFYFEDRRPVPMPSAPEVGQELVDLPASLSAKV
LLLNEMLSQKVSQSELARRLDTRPQEVQRIVNLDHTTKIDTIEAAFRALGRRIELRIT

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5KT30

Antitoxin

Source ID Structure

References