257852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 717898..718553 Replicon chromosome
Accession NZ_CP104386
Organism Cupriavidus gilardii strain WM02

Toxin (Protein)


Gene name vapC Uniprot ID V2FYH0
Locus tag N4G38_RS03370 Protein ID WP_006577198.1
Coordinates 718152..718553 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N4G38_RS03365 Protein ID WP_260731043.1
Coordinates 717898..718152 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G38_RS03350 (N4G38_03350) 713249..715216 + 1968 WP_260731041.1 hypothetical protein -
N4G38_RS03355 (N4G38_03355) 715236..715850 - 615 WP_006577195.1 glutathione S-transferase N-terminal domain-containing protein -
N4G38_RS03360 (N4G38_03360) 716268..717659 + 1392 WP_260731042.1 adenylosuccinate lyase -
N4G38_RS03365 (N4G38_03365) 717898..718152 + 255 WP_260731043.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N4G38_RS03370 (N4G38_03370) 718152..718553 + 402 WP_006577198.1 type II toxin-antitoxin system VapC family toxin Toxin
N4G38_RS03375 (N4G38_03375) 718726..719274 + 549 WP_260731044.1 cytochrome b -
N4G38_RS03380 (N4G38_03380) 719361..719933 + 573 WP_053822490.1 YceI family protein -
N4G38_RS03385 (N4G38_03385) 720032..720622 + 591 WP_174782151.1 YceI family protein -
N4G38_RS03390 (N4G38_03390) 721119..722510 + 1392 WP_174782150.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(17-52)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.51 Da        Isoelectric Point: 7.9095

>T257852 WP_006577198.1 NZ_CP104386:718152-718553 [Cupriavidus gilardii]
MALYLLDTNIVSAALRNTRGACAARIGMTDAGALCTSIVVAAELRFGVAKKGSAELARRVEHALSTLRVLPLDGDADRHY
GRLRTELERHGKPIGANDMLIAAHALAIDAVLVTDNVSEFSRVPGLRYENWLT

Download         Length: 402 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9694.97 Da        Isoelectric Point: 4.5482

>AT257852 WP_260731043.1 NZ_CP104386:717898-718152 [Cupriavidus gilardii]
MTTKTDATSEARHVRLFRNGRNQAVRIPREFELPGEEAIMRKEGDKLIIEPIPATSFRALLAQWEPLDETWPDIDDRPPE
PVDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V2FYH0

Antitoxin

Source ID Structure

References