Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3485940..3486558 Replicon chromosome
Accession NZ_CP104384
Organism Escherichia coli strain JNQH498

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KIG00_RS17060 Protein ID WP_001291435.1
Coordinates 3486340..3486558 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KIG00_RS17055 Protein ID WP_000344800.1
Coordinates 3485940..3486314 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIG00_RS17045 (3481029) 3481029..3482222 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KIG00_RS17050 (3482245) 3482245..3485394 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KIG00_RS17055 (3485940) 3485940..3486314 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KIG00_RS17060 (3486340) 3486340..3486558 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KIG00_RS17065 (3486730) 3486730..3487281 + 552 WP_000102564.1 maltose O-acetyltransferase -
KIG00_RS17070 (3487397) 3487397..3487867 + 471 WP_000136192.1 YlaC family protein -
KIG00_RS17075 (3488031) 3488031..3489581 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KIG00_RS17080 (3489623) 3489623..3489976 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KIG00_RS17090 (3490355) 3490355..3490666 + 312 WP_000409911.1 MGMT family protein -
KIG00_RS17095 (3490697) 3490697..3491269 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257845 WP_001291435.1 NZ_CP104384:3486340-3486558 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257845 WP_000344800.1 NZ_CP104384:3485940-3486314 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References