Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2420946..2421584 Replicon chromosome
Accession NZ_CP104384
Organism Escherichia coli strain JNQH498

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KIG00_RS11835 Protein ID WP_000813794.1
Coordinates 2421408..2421584 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KIG00_RS11830 Protein ID WP_001270286.1
Coordinates 2420946..2421362 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIG00_RS11810 (2416098) 2416098..2417039 - 942 WP_001251304.1 ABC transporter permease -
KIG00_RS11815 (2417040) 2417040..2418053 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
KIG00_RS11820 (2418071) 2418071..2419216 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KIG00_RS11825 (2419461) 2419461..2420867 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KIG00_RS11830 (2420946) 2420946..2421362 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KIG00_RS11835 (2421408) 2421408..2421584 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KIG00_RS11840 (2421806) 2421806..2422036 + 231 WP_000494244.1 YncJ family protein -
KIG00_RS11845 (2422128) 2422128..2424089 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KIG00_RS11850 (2424162) 2424162..2424698 - 537 WP_080317363.1 DNA-binding transcriptional regulator SutR -
KIG00_RS11855 (2424751) 2424751..2425965 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257844 WP_000813794.1 NZ_CP104384:c2421584-2421408 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257844 WP_001270286.1 NZ_CP104384:c2421362-2420946 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References