Detailed information of TA system TA025784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3971958..3972523
• Replicon: chromosome
• Accession: NC_016631
• Organism: Granulicella mallensis MP5ACTX8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G8NT57
• Locus tag: ACIX8_RS15780
• Protein ID: WP_014266363.1
• Coordinates: 3972230..3972523 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G8NT56
• Locus tag: ACIX8_RS15775
• Protein ID: WP_014266362.1
• Coordinates: 3971958..3972242 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACIX8_RS15750	3967487..3967732	+	246	WP_014266357.1	zf-HC2 domain-containing protein	-
ACIX8_RS15755	3968076..3968960	-	885	Protein_3094	hypothetical protein	-
ACIX8_RS15760	3969139..3970038	-	900	WP_150110889.1	glutamate formimidoyltransferase	-
ACIX8_RS15765	3970199..3970930	-	732	WP_014266360.1	acyloxyacyl hydrolase	-
ACIX8_RS15770	3971002..3971742	-	741	WP_014266361.1	YebC/PmpR family DNA-binding transcriptional regulator	-
ACIX8_RS15775	3971958..3972242	+	285	WP_014266362.1	ribbon-helix-helix protein, CopG family	Antitoxin
ACIX8_RS15780	3972230..3972523	+	294	WP_014266363.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACIX8_RS15785	3972559..3973893	-	1335	WP_083836696.1	diaminopimelate decarboxylase	-
ACIX8_RS25300	3973827..3974147	-	321	WP_014266365.1	PspC domain-containing protein	-
ACIX8_RS15790	3974216..3975202	-	987	WP_150110890.1	hypothetical protein	-
ACIX8_RS15795	3975578..3975850	+	273	WP_014266367.1	hypothetical protein	-
ACIX8_RS15800	3975940..3977328	+	1389	WP_014266368.1	carboxypeptidase-like regulatory domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11133.99 Da
• Isoelectric Point: 8.5627

>T25784 WP_014266363.1 NC_016631:3972230-3972523 [Granulicella mallensis MP5ACTX8]
MPRLIWSPEAVEDLVRLHAFLVTKSPDAARRAIKAIRQQVKPLARHPEAGRFIEDMLPEFMEWFIEFGSSGYLALYHFDG
KKVVILAVRHGLEAGYQ

Nucleotide

• Length: 294 bp

>T25784 NC_016631:3972230-3972523 [Granulicella mallensis MP5ACTX8]
ATGCCACGTCTAATCTGGTCACCTGAAGCCGTTGAGGATTTAGTTCGCCTGCACGCTTTTCTGGTAACCAAGAGCCCTGA
TGCGGCCAGACGCGCTATCAAGGCAATTCGTCAGCAGGTAAAGCCTCTGGCACGGCACCCTGAAGCTGGCCGATTCATTG
AGGACATGCTGCCAGAGTTCATGGAATGGTTCATTGAATTCGGCAGCAGCGGCTATCTTGCCCTCTACCACTTCGATGGC
AAAAAGGTCGTCATTCTGGCTGTTCGTCATGGACTTGAAGCAGGGTATCAATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10826.20 Da
• Isoelectric Point: 7.3581

>AT25784 WP_014266362.1 NC_016631:3971958-3972242 [Granulicella mallensis MP5ACTX8]
MATASTTSLKLDLELKKRVQHLAESRRRSSHWLMIDAIETYVDREEKREEYRQAGLAAWNNYQTTGLHLTAEEADSWLAK
LENGEKAKAPKCHV

Nucleotide

• Length: 285 bp

>AT25784 NC_016631:3971958-3972242 [Granulicella mallensis MP5ACTX8]
ATGGCTACAGCTTCTACAACCAGTCTGAAGCTCGATCTCGAGCTAAAAAAACGCGTGCAGCATTTAGCCGAATCGAGACG
CAGAAGCTCCCACTGGCTCATGATTGATGCCATTGAAACGTATGTCGATCGCGAAGAAAAGCGAGAAGAATATCGCCAGG
CCGGCCTTGCCGCCTGGAACAACTACCAGACCACAGGCCTGCACCTGACGGCAGAAGAGGCCGATAGCTGGCTTGCAAAA
TTGGAAAATGGCGAAAAGGCCAAAGCTCCTAAATGCCACGTCTAA

Structures

Toxin

• AlphaFold DB: G8NT57

Antitoxin

• AlphaFold DB: G8NT56