Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3405637..3407259 Replicon chromosome
Accession NZ_CP104377
Organism Comamonas sp. PR12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N4T19_RS15885 Protein ID WP_260718499.1
Coordinates 3405637..3406986 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N4T19_RS15890 Protein ID WP_116927469.1
Coordinates 3406990..3407259 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T19_RS15860 (N4T19_15860) 3400969..3402330 + 1362 WP_182344202.1 glycerophosphodiester phosphodiesterase family protein -
N4T19_RS15865 (N4T19_15865) 3402388..3403077 - 690 WP_260718496.1 amino acid ABC transporter permease -
N4T19_RS15870 (N4T19_15870) 3403074..3403841 - 768 WP_260718497.1 amino acid ABC transporter permease -
N4T19_RS15875 (N4T19_15875) 3403910..3404713 - 804 WP_232539627.1 ABC transporter substrate-binding protein -
N4T19_RS15880 (N4T19_15880) 3404985..3405590 + 606 WP_260718498.1 DUF4304 domain-containing protein -
N4T19_RS15885 (N4T19_15885) 3405637..3406986 - 1350 WP_260718499.1 type II toxin-antitoxin system HipA family toxin Toxin
N4T19_RS15890 (N4T19_15890) 3406990..3407259 - 270 WP_116927469.1 helix-turn-helix transcriptional regulator Antitoxin
N4T19_RS15895 (N4T19_15895) 3407387..3410140 - 2754 WP_182344210.1 methionine synthase -
N4T19_RS15900 (N4T19_15900) 3410514..3411752 + 1239 WP_182344212.1 sodium/glutamate symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 50020.39 Da        Isoelectric Point: 6.5012

>T257830 WP_260718499.1 NZ_CP104377:c3406986-3405637 [Comamonas sp. PR12]
MRSVGHNKALGLWMNGHRVGTWRVEAGSDVLQYDDAWVRDVALRRPLSLSLPFTPGNGPHKGEAVRFYFQNLLPDNEQIL
ERIARRYKVGATDPNALLQEIGRDCVGALQILPAGEAPPEEPEMQYEVLSEADVARLVRAVVNPTQSGDGGLDDDDFRIS
IAGAQEKTALLYWAGQWCRPLGATPTSHILKLPLGLIGNMQIDMRHSVENEWLCSKLVAAFGIPIAPCDVLRFEDQKVLA
VERFDRSVWKEKVLVRIPQEDMCQASGVSPILKYESDGGPGVDTIMDLLARSKSPGTDRFQFFMAQLLFWMLCATDGHAK
NFSIFLRPQGVFEMTPLYDVLSAYPIWGAGPGKLSPHKARMAMAVRSKNAHWNMNKIMRCHWEAVGERYGIRSPQGLDVR
AIIDQVVEMTPDVIARAEKQLPPDFPQSVSTAIFQGLQDAANRLGRVHD

Download         Length: 1350 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9805.32 Da        Isoelectric Point: 10.2947

>AT257830 WP_116927469.1 NZ_CP104377:c3407259-3406990 [Comamonas sp. PR12]
MDEFTVRTTAQLPTLLKAFRKTAKLTQADVATRLGVTQQTVSAMERNAESVSAERLMKLMGILGVDLVLRARPATSPDTG
RELQTLDSW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References