Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2800348..2801936 Replicon chromosome
Accession NZ_CP104373
Organism Klebsiella pneumoniae strain 2021CK-01815

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N4558_RS13610 Protein ID WP_019705665.1
Coordinates 2800348..2801670 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N4558_RS13615 Protein ID WP_004176198.1
Coordinates 2801670..2801936 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4558_RS13595 (N4558_13595) 2795404..2797905 + 2502 WP_019705666.1 fimbria/pilus outer membrane usher protein -
N4558_RS13600 (N4558_13600) 2797893..2798897 + 1005 WP_004184029.1 fimbrial protein -
N4558_RS13605 (N4558_13605) 2799039..2800331 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N4558_RS13610 (N4558_13610) 2800348..2801670 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
N4558_RS13615 (N4558_13615) 2801670..2801936 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N4558_RS13620 (N4558_13620) 2802202..2802528 - 327 WP_019705664.1 hydroxyisourate hydrolase -
N4558_RS13625 (N4558_13625) 2802525..2803025 - 501 WP_019705663.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N4558_RS13630 (N4558_13630) 2803003..2804382 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
N4558_RS13635 (N4558_13635) 2804728..2805882 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N4558_RS13640 (N4558_13640) 2805863..2806786 - 924 WP_019705662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T257822 WP_019705665.1 NZ_CP104373:c2801670-2800348 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT257822 WP_004176198.1 NZ_CP104373:c2801936-2801670 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References