Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 777201..777858 Replicon chromosome
Accession NZ_CP104373
Organism Klebsiella pneumoniae strain 2021CK-01815

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N4558_RS03850 Protein ID WP_002916310.1
Coordinates 777448..777858 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N4558_RS03845 Protein ID WP_002916312.1
Coordinates 777201..777467 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4558_RS03820 (N4558_03820) 772409..773842 - 1434 WP_019704912.1 6-phospho-beta-glucosidase BglA -
N4558_RS03825 (N4558_03825) 773961..774689 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N4558_RS03830 (N4558_03830) 774739..775050 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N4558_RS03835 (N4558_03835) 775214..775873 + 660 WP_002916317.1 hemolysin III family protein -
N4558_RS03840 (N4558_03840) 775972..776955 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
N4558_RS03845 (N4558_03845) 777201..777467 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N4558_RS03850 (N4558_03850) 777448..777858 + 411 WP_002916310.1 protein YgfX Toxin
N4558_RS03855 (N4558_03855) 777865..778386 - 522 WP_004144730.1 flavodoxin FldB -
N4558_RS03860 (N4558_03860) 778487..779383 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N4558_RS03865 (N4558_03865) 779406..780119 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4558_RS03870 (N4558_03870) 780125..781858 + 1734 WP_019704911.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T257817 WP_002916310.1 NZ_CP104373:777448-777858 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT257817 WP_002916312.1 NZ_CP104373:777201-777467 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References