Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4266406..4267024 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4502_RS20495 Protein ID WP_001291435.1
Coordinates 4266406..4266624 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4502_RS20500 Protein ID WP_000344800.1
Coordinates 4266650..4267024 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS20460 (4261695) 4261695..4262267 + 573 WP_000779833.1 YbaY family lipoprotein -
N4502_RS20465 (4262298) 4262298..4262609 - 312 WP_000409911.1 MGMT family protein -
N4502_RS20475 (4262988) 4262988..4263341 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N4502_RS20480 (4263383) 4263383..4264933 - 1551 WP_001305493.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4502_RS20485 (4265097) 4265097..4265567 - 471 WP_000136192.1 YlaC family protein -
N4502_RS20490 (4265683) 4265683..4266234 - 552 WP_000102564.1 maltose O-acetyltransferase -
N4502_RS20495 (4266406) 4266406..4266624 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N4502_RS20500 (4266650) 4266650..4267024 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4502_RS20505 (4267570) 4267570..4270719 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
N4502_RS20510 (4270742) 4270742..4271935 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257813 WP_001291435.1 NZ_CP104371:c4266624-4266406 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257813 WP_000344800.1 NZ_CP104371:c4267024-4266650 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References