Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3530571..3531166 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag N4502_RS17005 Protein ID WP_000239581.1
Coordinates 3530816..3531166 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag N4502_RS17000 Protein ID WP_001223213.1
Coordinates 3530571..3530822 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS16990 (3526236) 3526236..3530015 + 3780 WP_039720326.1 autotransporter assembly complex protein TamB -
N4502_RS16995 (3530018) 3530018..3530359 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N4502_RS17000 (3530571) 3530571..3530822 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N4502_RS17005 (3530816) 3530816..3531166 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
N4502_RS17010 (3531245) 3531245..3531775 - 531 WP_000055075.1 inorganic diphosphatase -
N4502_RS17015 (3532085) 3532085..3533041 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N4502_RS17020 (3533181) 3533181..3534683 + 1503 WP_039720327.1 sugar ABC transporter ATP-binding protein -
N4502_RS17025 (3534697) 3534697..3535719 + 1023 WP_039720328.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T257809 WP_000239581.1 NZ_CP104371:3530816-3531166 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT257809 WP_001223213.1 NZ_CP104371:3530571-3530822 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References