Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2787510..2788122 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name hicA Uniprot ID A0A167AMN3
Locus tag N4502_RS13590 Protein ID WP_000833474.1
Coordinates 2787937..2788122 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag N4502_RS13585 Protein ID WP_000499746.1
Coordinates 2787510..2787920 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS13570 (2783022) 2783022..2783837 - 816 WP_000891823.1 AraC family transcriptional regulator -
N4502_RS13575 (2784063) 2784063..2785463 + 1401 WP_000204804.1 MFS transporter -
N4502_RS13580 (2785474) 2785474..2787438 + 1965 WP_001026871.1 glycoside hydrolase family 127 protein -
N4502_RS13585 (2787510) 2787510..2787920 - 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4502_RS13590 (2787937) 2787937..2788122 - 186 WP_000833474.1 type II toxin-antitoxin system HicA family toxin Toxin
N4502_RS13595 (2788391) 2788391..2789929 - 1539 WP_001306609.1 aldehyde dehydrogenase AldB -
N4502_RS13600 (2790130) 2790130..2791281 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6819.94 Da        Isoelectric Point: 12.0345

>T257807 WP_000833474.1 NZ_CP104371:c2788122-2787937 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSRHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT257807 WP_000499746.1 NZ_CP104371:c2787920-2787510 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167AMN3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References