Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2016021..2016675 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N4502_RS09800 Protein ID WP_000244781.1
Coordinates 2016021..2016428 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N4502_RS09805 Protein ID WP_000354046.1
Coordinates 2016409..2016675 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS09780 (2011978) 2011978..2013711 - 1734 WP_000813175.1 single-stranded-DNA-specific exonuclease RecJ -
N4502_RS09785 (2013717) 2013717..2014427 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4502_RS09790 (2014452) 2014452..2015348 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N4502_RS09795 (2015460) 2015460..2015981 + 522 WP_001055888.1 flavodoxin FldB -
N4502_RS09800 (2016021) 2016021..2016428 - 408 WP_000244781.1 protein YgfX Toxin
N4502_RS09805 (2016409) 2016409..2016675 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N4502_RS09810 (2016918) 2016918..2017898 + 981 WP_000886051.1 tRNA-modifying protein YgfZ -
N4502_RS09815 (2017975) 2017975..2018634 - 660 WP_000250274.1 hemolysin III family protein -
N4502_RS09820 (2018798) 2018798..2019109 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
N4502_RS09825 (2019154) 2019154..2020587 + 1434 WP_001305827.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T257804 WP_000244781.1 NZ_CP104371:c2016428-2016021 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT257804 WP_000354046.1 NZ_CP104371:c2016675-2016409 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References