Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1295756..1296461 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N4502_RS06355 Protein ID WP_000539521.1
Coordinates 1295756..1296142 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N4502_RS06360 Protein ID WP_001280945.1
Coordinates 1296132..1296461 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS06335 (1291760) 1291760..1292386 + 627 WP_001314584.1 glutathione S-transferase GstB -
N4502_RS06340 (1292383) 1292383..1293498 - 1116 WP_000555033.1 aldose sugar dehydrogenase YliI -
N4502_RS06345 (1293609) 1293609..1293992 - 384 WP_000497137.1 biofilm formation regulator BssR -
N4502_RS06350 (1294205) 1294205..1295530 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N4502_RS06355 (1295756) 1295756..1296142 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4502_RS06360 (1296132) 1296132..1296461 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N4502_RS06365 (1296531) 1296531..1297859 - 1329 WP_000086873.1 GGDEF domain-containing protein -
N4502_RS06370 (1297867) 1297867..1300215 - 2349 Protein_1255 EAL domain-containing protein -
N4502_RS06375 (1300393) 1300393..1301304 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T257803 WP_000539521.1 NZ_CP104371:1295756-1296142 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT257803 WP_001280945.1 NZ_CP104371:1296132-1296461 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References