Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 439019..439584 Replicon chromosome
Accession NC_016630
Organism Filifactor alocis ATCC 35896

Toxin (Protein)


Gene name relE Uniprot ID D6GRN6
Locus tag HMPREF0389_RS01970 Protein ID WP_014262063.1
Coordinates 439306..439584 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D6GRN7
Locus tag HMPREF0389_RS01965 Protein ID WP_014262062.1
Coordinates 439019..439306 (+) Length 96 a.a.

Genomic Context

HMPREF0389_RS01965HMPREF0389_RS01970HMPREF0389_RS01940HMPREF0389_RS01945HMPREF0389_RS01950HMPREF0389_RS01955HMPREF0389_RS01960HMPREF0389_RS09070HMPREF0389_RS08985HMPREF0389_RS01975HMPREF0389_RS01980HMPREF0389_RS01985
Location: 439019..439306 (288 bp)
Type: Antitoxin
Protein ID: WP_014262062.1
Location: 439306..439584 (279 bp)
Type: Toxin
Protein ID: WP_014262063.1
Location: 434602..435999 (1398 bp)
Type: Others
Protein ID: WP_014262057.1
Location: 436074..436355 (282 bp)
Type: Others
Protein ID: WP_014262058.1
Location: 436425..436766 (342 bp)
Type: Others
Protein ID: WP_014262059.1
Location: 436807..438090 (1284 bp)
Type: Others
Protein ID: WP_169308509.1
Location: 438228..438758 (531 bp)
Type: Others
Protein ID: WP_014262061.1
Location: 438755..438928 (174 bp)
Type: Others
Protein ID: WP_009531054.1
Location: 439618..439779 (162 bp)
Type: Others
Protein ID: WP_156775228.1
Location: 439779..440465 (687 bp)
Type: Others
Protein ID: WP_014262064.1
Location: 440455..440694 (240 bp)
Type: Others
Protein ID: WP_014262065.1
Location: 440716..442557 (1842 bp)
Type: Others
Protein ID: WP_014262066.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HMPREF0389_RS01940434602..435999-1398WP_014262057.1relaxase/mobilization nuclease domain-containing protein-
HMPREF0389_RS01945436074..436355-282WP_014262058.1hypothetical protein-
HMPREF0389_RS01950436425..436766-342WP_014262059.1mobilization protein-
HMPREF0389_RS01955436807..438090-1284WP_169308509.1antirestriction protein ArdA-
HMPREF0389_RS01960438228..438758-531WP_014262061.1DNA repair protein RadC-
HMPREF0389_RS09070438755..438928-174WP_009531054.1hypothetical protein-
HMPREF0389_RS01965439019..439306+288WP_014262062.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HMPREF0389_RS01970439306..439584+279WP_014262063.1type II toxin-antitoxin system YafQ family toxinToxin
HMPREF0389_RS08985439618..439779-162WP_156775228.1hypothetical protein-
HMPREF0389_RS01975439779..440465-687WP_014262064.1DUF4366 domain-containing protein-
HMPREF0389_RS01980440455..440694-240WP_014262065.1DUF4315 family protein-
HMPREF0389_RS01985440716..442557-1842WP_014262066.1C40 family peptidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--394269..47454480275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-90)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10562.19 Da        Isoelectric Point: 8.0688

>T25780 WP_014262063.1 NC_016630:439306-439584 [Filifactor alocis ATCC 35896]
MLELVTTGAFRKDLKLAKKRGYDLSLLETVLNTLLEEKTLDQRYHDHALTGNYIGFRECHILPDWLLIYAVNKSQLILTA
SRTGTHSDLFGR

Download         Length: 279 bp

>T25780 NC_016630:439306-439584 [Filifactor alocis ATCC 35896]
ATGTTAGAGCTTGTAACCACAGGTGCCTTTCGCAAGGATTTGAAACTTGCCAAAAAGCGAGGCTACGATCTGTCTTTGCT
TGAAACGGTACTAAATACTCTTTTAGAAGAAAAAACCTTGGATCAGCGTTATCACGACCATGCTTTAACCGGAAATTATA
TCGGGTTTCGAGAATGTCATATCCTGCCGGATTGGCTGCTTATTTATGCAGTAAATAAATCACAACTGATCCTCACAGCT
TCAAGGACGGGAACGCATTCCGATTTGTTTGGGAGATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10601.19 Da        Isoelectric Point: 4.5431

>AT25780 WP_014262062.1 NC_016630:439019-439306 [Filifactor alocis ATCC 35896]
MAKTANINVRIDPETKASAEQLFSSFGITVTDAINIFLHKSLMEGGLPFEMKQPRFNLETEMAMEEAKLIMAGKIPAKRY
ASVHELLDELETDGE

Download         Length: 288 bp

>AT25780 NC_016630:439019-439306 [Filifactor alocis ATCC 35896]
ATGGCAAAAACGGCGAATATCAATGTACGTATTGATCCGGAAACAAAAGCAAGTGCGGAACAGTTATTTTCAAGCTTTGG
AATTACCGTAACCGATGCCATCAATATTTTTCTTCATAAATCACTGATGGAGGGAGGGCTTCCTTTTGAAATGAAACAGC
CTCGTTTCAACTTGGAAACGGAAATGGCGATGGAGGAAGCAAAGCTCATTATGGCAGGAAAAATTCCCGCCAAGCGTTAT
GCCTCGGTACACGAGTTATTGGATGAGCTGGAAACGGATGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD6GRN6

Antitoxin

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Source
ID
Structure
AlphaFold DBD6GRN7

References