Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4346250..4347031 | Replicon | chromosome |
| Accession | NZ_CP104366 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | N4533_RS21275 | Protein ID | WP_000626099.1 |
| Coordinates | 4346250..4346741 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | N4533_RS21280 | Protein ID | WP_001110452.1 |
| Coordinates | 4346738..4347031 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N4533_RS21240 (4342245) | 4342245..4342820 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| N4533_RS21250 (4343091) | 4343091..4343168 | - | 78 | Protein_4154 | helix-turn-helix domain-containing protein | - |
| N4533_RS21255 (4343259) | 4343259..4343591 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| N4533_RS21260 (4343663) | 4343663..4344040 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| N4533_RS21265 (4345073) | 4345073..4345147 | + | 75 | Protein_4157 | porin family protein | - |
| N4533_RS21270 (4345250) | 4345250..4346002 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| N4533_RS21275 (4346250) | 4346250..4346741 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| N4533_RS21280 (4346738) | 4346738..4347031 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| N4533_RS21285 (4347348) | 4347348..4347569 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| N4533_RS21290 (4347834) | 4347834..4348709 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| N4533_RS21295 (4348706) | 4348706..4348993 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| N4533_RS21300 (4349016) | 4349016..4349231 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| N4533_RS21305 (4349239) | 4349239..4349508 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| N4533_RS21310 (4349802) | 4349802..4350707 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T257790 WP_000626099.1 NZ_CP104366:c4346741-4346250 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT257790 WP_001110452.1 NZ_CP104366:c4347031-4346738 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |