Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4217624..4218140 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag N4533_RS20610 Protein ID WP_000220578.1
Coordinates 4217624..4217908 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4533_RS20615 Protein ID WP_000212724.1
Coordinates 4217898..4218140 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS20595 (4212836) 4212836..4214488 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
N4533_RS20600 (4214897) 4214897..4217035 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N4533_RS20605 (4217156) 4217156..4217620 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4533_RS20610 (4217624) 4217624..4217908 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4533_RS20615 (4217898) 4217898..4218140 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4533_RS20620 (4218218) 4218218..4220131 - 1914 WP_001212137.1 BglG family transcription antiterminator -
N4533_RS20625 (4220148) 4220148..4220888 - 741 WP_000779263.1 KDGP aldolase family protein -
N4533_RS20630 (4220885) 4220885..4222003 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4533_RS20635 (4221987) 4221987..4223120 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T257789 WP_000220578.1 NZ_CP104366:c4217908-4217624 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT257789 WP_000212724.1 NZ_CP104366:c4218140-4217898 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References