Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4123363..4123939 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag N4533_RS20210 Protein ID WP_001131963.1
Coordinates 4123652..4123939 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag N4533_RS20205 Protein ID WP_000063142.1
Coordinates 4123363..4123665 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS20190 (4119873) 4119873..4122023 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
N4533_RS20195 (4122118) 4122118..4122321 + 204 WP_000460616.1 YbdD/YjiX family protein -
N4533_RS20200 (4122332) 4122332..4123288 + 957 WP_000187839.1 GTPase -
N4533_RS20205 (4123363) 4123363..4123665 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
N4533_RS20210 (4123652) 4123652..4123939 - 288 WP_001131963.1 BrnT family toxin Toxin
N4533_RS20215 (4124208) 4124208..4125122 - 915 WP_000290512.1 restriction endonuclease -
N4533_RS20220 (4125320) 4125320..4128829 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T257788 WP_001131963.1 NZ_CP104366:c4123939-4123652 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT257788 WP_000063142.1 NZ_CP104366:c4123665-4123363 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References