Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3523423..3524043 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4533_RS17455 Protein ID WP_001280991.1
Coordinates 3523825..3524043 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4533_RS17450 Protein ID WP_000344807.1
Coordinates 3523423..3523797 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS17440 (3518562) 3518562..3519755 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4533_RS17445 (3519778) 3519778..3522927 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4533_RS17450 (3523423) 3523423..3523797 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4533_RS17455 (3523825) 3523825..3524043 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4533_RS17460 (3524222) 3524222..3524773 + 552 WP_001278792.1 maltose O-acetyltransferase -
N4533_RS17465 (3524890) 3524890..3525360 + 471 WP_000136181.1 YlaC family protein -
N4533_RS17470 (3525416) 3525416..3525556 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4533_RS17475 (3525562) 3525562..3525822 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4533_RS17480 (3526047) 3526047..3527597 + 1551 WP_000213139.1 EAL domain-containing protein -
N4533_RS17490 (3527828) 3527828..3528217 + 390 WP_000961285.1 MGMT family protein -
N4533_RS17495 (3528250) 3528250..3528819 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T257785 WP_001280991.1 NZ_CP104366:3523825-3524043 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT257785 WP_000344807.1 NZ_CP104366:3523423-3523797 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References