Detailed information of TA system TA025778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 3844196..3844803
• Replicon: chromosome
• Accession: NC_016629
• Organism: Desulfovibrio africanus str. Walvis Bay

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: F3YXJ0
• Locus tag: DESAF_RS17450
• Protein ID: WP_014261381.1
• Coordinates: 3844456..3844803 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: F3YXI9
• Locus tag: DESAF_RS17445
• Protein ID: WP_014261380.1
• Coordinates: 3844196..3844462 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESAF_RS17430	3840656..3841102	-	447	WP_014261377.1	response regulator	-
DESAF_RS20520	3841089..3842561	-	1473	WP_014261378.1	HAMP domain-containing protein	-
DESAF_RS17440	3842568..3843560	-	993	WP_014261379.1	ABC transporter substrate-binding protein	-
DESAF_RS17445	3844196..3844462	+	267	WP_014261380.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DESAF_RS17450	3844456..3844803	+	348	WP_014261381.1	endoribonuclease MazF	Toxin
DESAF_RS17455	3844876..3845403	-	528	WP_014261382.1	acetyltransferase	-
DESAF_RS17460	3845400..3845678	-	279	WP_014261383.1	DUF1778 domain-containing protein	-
DESAF_RS17465	3846079..3849621	+	3543	WP_014261384.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (11-111)

Antitoxin

• SpoVT-AbrB domain (17-57)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12182.08 Da
• Isoelectric Point: 6.9775

>T25778 WP_014261381.1 NC_016629:3844456-3844803 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
MVSGSERVPDVGELIWINLDPQAGHEQAGKRPALVLSPQSYNAKAGLCLAAPITSQVKGYPFEVALPAGLAISGVILADQ
LKNLDWRARRATVADQAPPEVLAEVRGKLGALLQF

Nucleotide

• Length: 348 bp

>T25778 NC_016629:3844456-3844803 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
ATGGTAAGCGGGAGCGAGCGCGTTCCCGACGTCGGCGAGCTGATCTGGATCAACCTCGACCCGCAGGCCGGACACGAGCA
GGCAGGCAAGCGGCCGGCCCTGGTCCTGTCGCCGCAAAGCTACAACGCCAAGGCAGGCCTGTGTCTGGCCGCCCCGATCA
CCAGCCAGGTCAAGGGCTACCCCTTCGAGGTCGCCCTGCCGGCCGGACTGGCCATTTCAGGCGTCATCCTGGCCGATCAG
CTCAAGAACCTCGACTGGCGCGCCCGCCGCGCCACAGTGGCCGACCAGGCCCCGCCCGAGGTGCTGGCCGAGGTGCGCGG
CAAACTGGGTGCGCTGCTGCAGTTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9651.88 Da
• Isoelectric Point: 5.6999

>AT25778 WP_014261380.1 NC_016629:3844196-3844462 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
MATDSVQDVHGTAKVSRWGNSLGLRIPKAVSEAGELREGDLVEFLPAPQGFCIRKKRVYSLDELVAGISEENRHAEASWG
KPMGNEAW

Nucleotide

• Length: 267 bp

>AT25778 NC_016629:3844196-3844462 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
ATGGCAACTGATTCAGTGCAGGACGTGCACGGCACTGCCAAGGTTTCGCGCTGGGGCAACAGCCTGGGCCTGCGGATTCC
CAAGGCCGTCAGCGAGGCCGGCGAGCTGCGGGAAGGCGATCTGGTGGAGTTCCTGCCGGCCCCGCAGGGCTTCTGCATCC
GCAAGAAGCGGGTCTACTCGCTGGACGAGCTGGTCGCCGGCATCAGCGAGGAGAACAGGCATGCCGAAGCCTCCTGGGGC
AAGCCCATGGGGAACGAGGCATGGTAA

Structures

Toxin

• AlphaFold DB: F3YXJ0

Antitoxin

• AlphaFold DB: F3YXI9