Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837983..838643 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag N4533_RS04035 Protein ID WP_000244756.1
Coordinates 838230..838643 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag N4533_RS04030 Protein ID WP_000351186.1
Coordinates 837983..838249 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS04010 (833911) 833911..835344 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
N4533_RS04015 (835503) 835503..835814 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
N4533_RS04020 (835978) 835978..836637 + 660 WP_000250289.1 hemolysin III family protein -
N4533_RS04025 (836753) 836753..837733 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
N4533_RS04030 (837983) 837983..838249 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
N4533_RS04035 (838230) 838230..838643 + 414 WP_000244756.1 protein YgfX Toxin
N4533_RS04040 (838696) 838696..839217 - 522 WP_001055885.1 flavodoxin FldB -
N4533_RS04045 (839330) 839330..840226 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
N4533_RS04050 (840250) 840250..840963 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4533_RS04055 (840969) 840969..842702 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T257777 WP_000244756.1 NZ_CP104366:838230-838643 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT257777 WP_000351186.1 NZ_CP104366:837983-838249 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5


Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References